Senior Director, Medicinal Chemistry Design at Parabilis Medicines

The role

This role involves leading drug design teams to advance a transformational new modality called Helicons, including degraders and induced proximity approaches. Reporting to the VP of Medicinal Chemistry Design, the successful candidate will serve as a program leader driving programs from hit-to-lead through candidate nomination.

What you'll do

• Lead drug design teams using an AI platform for rapid decision making
• Set strategy and coordinate cross-functional teams as a program leader
• Develop and implement integrated medicinal chemistry strategies for lead optimization
• Apply hypothesis-based drug design and in silico methods to solve optimization issues
• Collaborate with data scientists to evolve machine learning models for the platform
• Work with IP counsel to formulate strategies and draft patent applications

What you'll bring

• PhD in chemistry with twelve plus years of industrial experience
• Proven track record of delivering drug candidates as a program leader
• Expertise in optimizing induced proximity modalities such as protein degraders
• Proficiency in structure-based data analysis and hypothesis-driven design
• Ability to utilize AI tools and work on-site in Cambridge

Your impact

The individual will drive the progression of lead molecules to pharmacological proof-of-concept and development candidate nomination, directly contributing to the company's mission of drugging previously unreachable targets. By integrating medicinal chemistry with AI and machine learning, they will accelerate the delivery of life-altering medicines for patients with serious diseases.